Pope Gregory announces the death of Santa Fina, in the Collegiate Church of San Gimignano (about 1477)

The Adoration of the Shepherds, Sassetti Chapel, contains a portrait of Ghirlandaio as one of the Shepherds

Detail of the Angel appearing to Zacharias showing portraits of the philosophers Marsilio Ficino, Cristoforo Landino, Angelo Poliziano and Demetrios Chalkondyles

More details The Birth of Mary, Tornabuoni Chapel (1485-90)

appears to represent a domestic scene from the life of contemporary Florentine nobility